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In Vitro Difference between an Attenuated ML-17 and its Parental Virulent JaOH0566 Strain of Japanese Encephalitis Virus


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Title: In Vitro Difference between an Attenuated ML-17 and its Parental Virulent JaOH0566 Strain of Japanese Encephalitis Virus
Authors: Shameem, Golam Masud Mohammad / Morita, Kouichi / Tanaka, Mariko / Igarashi, Akira
Issue Date: 30-Jun-1989
Publisher: 長崎大学熱帯医学研究所 / Institute of Tropical Medicine, Nagasaki University
Citation: 熱帯医学 Tropical medicine 31(2). p67-74, 1989
Abstract: Two Japanese encephalitis (JE) virus strains, namely a virulent JaOH0556 and an attenuated ML-17 derived from it were studied to investigate their in vitro phenotypic differences. When both strains were concentrated by polyethylene glycol (PEG) 6000 precipitation, infectivity of the ML-17 was recovered only 4.94% compared to 42.21% for the parental JaOH0566 strain, and the virion peak was very low for the ML-17 in contrast to a sharp peak for the JaOH0566 in sucrose density gradient centrifugation. When both strains were incubated with sucrose solutions, the ML-17 was slightly more labile than the JaOH0566 at high concentration of sucrose. These findings may indicate difference in the virion structure of both strains.
URI: http://hdl.handle.net/10069/4544
ISSN: 03855643
Type: Departmental Bulletin Paper
Appears in Collections:Volume 31, No. 2

Citable URI : http://hdl.handle.net/10069/4544

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