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Comparative Amino Acid Sequences of Dengue Viruses


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Title: Comparative Amino Acid Sequences of Dengue Viruses
Authors: Haishi, Shozo / Tanaka, Mariko / Igarashi, Akira
Issue Date: 30-Jun-1990
Publisher: 長崎大学熱帯医学研究所 / Institute of Tropical Medicine, Nagasaki University
Citation: 熱帯医学 Tropical medicine 32(2). p81-87, 1990
Abstract: Amino acid (AA) sequences of 4 serotype of dengue viruses deduced from their nucleotide (nt) sequences of genomic RNA were analyzed for each genome segment and each stretch of 10 AA residues. Precursor of membrane protein (pM), and 4 nonstructural proteins (NS1, NS3, NS4B, NS5) were highly conserved, while another nonstructural protein (NS2A) was least conserved among 5 strains of dengue viruses. When homology was compared among heterotypic viruses, type 1 and type 3 dengue viruses showed close relationships, while type 4 dengue virus was relatively remote from other types. When AA sequences were compared for each 10 AA residues, some highly conserved as well as least conserved domains were identified. Significance of these findings for diagnostic virology and epidemiological survey was discussed.
URI: http://hdl.handle.net/10069/4566
ISSN: 03855643
Type: Departmental Bulletin Paper
Appears in Collections:Volume 32, No. 2

Citable URI : http://hdl.handle.net/10069/4566

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