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Cytotoxic Activities of Lymphokine-activated Killer Cells and Chemotherapy-activated Killer Cells are Inhibited by Cholera Toxin


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タイトル: Cytotoxic Activities of Lymphokine-activated Killer Cells and Chemotherapy-activated Killer Cells are Inhibited by Cholera Toxin
著者: Kiyohara, Tatsuo / Watanabe, Masami / Ichinose, Yoshio / Naito, Tatsuro / Nakamura, Michio / Itakura, Hideyo
発行日: 1992年 3月21日
出版者: 長崎大学熱帯医学研究所 / Institute of Tropical Medicine, Nagasaki University
引用: 熱帯医学 Tropical medicine 34(1). p21-27, 1992
抄録: Cholera toxin added to an assay mixture significantly inhibited the cytotoxic activity of lymphokine-activated killer (LAK) cells derived from normal human peripheral blood leukocytes (PBLs). LAK cells preincubated with the toxin lost 90% of their cytolytic activity. In vitro activation of killer cells by Interleukin-2 from PBLs was not affected by the toxin. These results indicate that LAK cells are directly impaired of the cytolytic activity by the toxin and that the generation of LAK cells is not inhibited by it. LAK cells from a HIV carrier were more sensitive to the toxin than those from normal controls. Chemotherapy-activated killer (CAK) cells (Kiyohara et al., 1988) which had been activated in vivo were also impaired of the cytotoxic function by the toxin.
URI: http://hdl.handle.net/10069/4593
ISSN: 03855643
資料タイプ: Departmental Bulletin Paper
出現コレクション:第34巻 第1号

引用URI : http://hdl.handle.net/10069/4593

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