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Cytotoxic Activities of Lymphokine-activated Killer Cells and Chemotherapy-activated Killer Cells are Inhibited by Cholera Toxin


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Title: Cytotoxic Activities of Lymphokine-activated Killer Cells and Chemotherapy-activated Killer Cells are Inhibited by Cholera Toxin
Authors: Kiyohara, Tatsuo / Watanabe, Masami / Ichinose, Yoshio / Naito, Tatsuro / Nakamura, Michio / Itakura, Hideyo
Issue Date: 21-Mar-1992
Publisher: 長崎大学熱帯医学研究所 / Institute of Tropical Medicine, Nagasaki University
Citation: 熱帯医学 Tropical medicine 34(1). p21-27, 1992
Abstract: Cholera toxin added to an assay mixture significantly inhibited the cytotoxic activity of lymphokine-activated killer (LAK) cells derived from normal human peripheral blood leukocytes (PBLs). LAK cells preincubated with the toxin lost 90% of their cytolytic activity. In vitro activation of killer cells by Interleukin-2 from PBLs was not affected by the toxin. These results indicate that LAK cells are directly impaired of the cytolytic activity by the toxin and that the generation of LAK cells is not inhibited by it. LAK cells from a HIV carrier were more sensitive to the toxin than those from normal controls. Chemotherapy-activated killer (CAK) cells (Kiyohara et al., 1988) which had been activated in vivo were also impaired of the cytotoxic function by the toxin.
URI: http://hdl.handle.net/10069/4593
ISSN: 03855643
Type: Departmental Bulletin Paper
Appears in Collections:Volume 34, No. 1

Citable URI : http://hdl.handle.net/10069/4593

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