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Brugia malayi in Mastomys natalensis : Effect of Immunostimulators on Establishment and Course of Infection


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Title: Brugia malayi in Mastomys natalensis : Effect of Immunostimulators on Establishment and Course of Infection
Authors: Murthy, P. K. / Haq, W. / Tyagi, K. / Mathur, K. B. / Chatterjee, R. K.
Issue Date: 30-Jun-1992
Publisher: 長崎大学熱帯医学研究所 / Institute of Tropical Medicine, Nagasaki University
Citation: 熱帯医学 Tropical medicine 34(2). p63-69, 1992
Abstract: Effect of three immunomodulators (IMS), muramyl dipeptide (MDP), Freund's complete adjuvant (FCA) and a newly synthesized sugar free immunomodulator (CDRI Comp. No. 84/201) on the establishment and course of Brugia malayi infection in Mastomys natalensis was evaluated. These immunomodulators were administered on three occasions (days -10, 0 and +15 of larval exposure) by subcutaneous route. All the three immunostimulators caused prolongation of prepatent period of the infection, the longest being observed with Comp. 84/201 (136.6 days) followed by MDP (120 days) and FCA (118.82 days). Comp. 84/201 and MDP treated animals revealed significantly suppressed microfilaraemia (P<0.01) and less percentage of worm recovery over untreated infected controls. It is, thus, surmised that establishment of filarial infection be affected by immunomodulators and a Comp. 84/201, a non-pyrogenic immunomodulator holds promise for the purpose.
URI: http://hdl.handle.net/10069/4597
ISSN: 03855643
Type: Departmental Bulletin Paper
Appears in Collections:Volume 34, No. 2

Citable URI : http://hdl.handle.net/10069/4597

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