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Comparative Nucleotide and Amino Acid Sequences Among Seven Hepatitis C Virus cDNA Isolates in Japan and U.S.A.


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Title: Comparative Nucleotide and Amino Acid Sequences Among Seven Hepatitis C Virus cDNA Isolates in Japan and U.S.A.
Authors: Zheng, Wei-Yun / Kurihara, Shintaro / Morita, Kouichi / Tanaka, Mariko / Igarashi, Akira
Issue Date: 30-Sep-1992
Publisher: 長崎大学熱帯医学研究所 / Institute of Tropical Medicine, Nagasaki University
Citation: 熱帯医学 Tropical medicine 34(3). p105-112, 1992
Abstract: The nucleotide and deduced amino acid sequence homology of hepatitis C virus (HCV) among seven HCV CDNA isolates in Japan and U.S.A. have been compared and discussed. It was found that Okamoto's nucleotide sequence (J1) has high homology (>94.1%) with American (CHIRON) in both nucleotide and amino acid sequence. Kato's nucleotide sequence (JGC) was close to Takamizawa's nucleotide sequence (JBK), with similarity of >87.0% for both nucleotide and amino acid. CHIRON was closer to JGC and JBK than to Okamoto's nucleotide sequence (J6). J6 was different from each of the other six isolates. The high degree of sequence conservation in the 5' non-coding region among six isolates (>92.8%) except Takeuchi's nucleotide sequence (JYK) has been observed. The low level of nucleotide and amino acid sequence variation in the putative core protein and the variability of putative envelope glycoprotein among seven isolates have been observed.
URI: http://hdl.handle.net/10069/4603
ISSN: 03855643
Type: Departmental Bulletin Paper
Appears in Collections:Volume 34, No. 3

Citable URI : http://hdl.handle.net/10069/4603

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