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Prevalence of Antimicrobial Resistance in Haemophilus influenzae and Streptococcus pneumoniae : Comparison of Clinical Isolates of Japan and The Philippines


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タイトル: Prevalence of Antimicrobial Resistance in Haemophilus influenzae and Streptococcus pneumoniae : Comparison of Clinical Isolates of Japan and The Philippines
著者: Tateda, Kazuhiro / Tomono, Kazunori / Hirakata, Yoichi / Furuya, Nobuhiko / Sugahara, Kazuyuki / Saniel, M. C. / Tupasi, T. E. / Yamaguchi, Keizo
発行日: 1993年10月20日
出版者: 長崎大学熱帯医学研究所 / Institute of Tropical Medicine, Nagasaki University
引用: 熱帯医学 Tropical medicine 35(2). p43-52, 1993
抄録: For clinical isolates of Haemophilus influenzae and Streptococcus pneumoniae in Japan (356 and 179 strains, respectively) and in the Philippines (98 and 59 strains, respectively), minimum inhibitory concentrations (MICs) of ampicillin, cefazolin, cefotiam, ceftizoxim, ofloxacin, erythromycin, and minocycline were examined. The rates of β-lactamase producing H. influenzae were 17.7% (63/356) in Japan and 2.0% (2/98) in the Philippines, and all of these strains were ampicillin MICs 〓1.56 ugml^<-1>. In addition, 5 strains in Japan that lacked β-lactamase activity were also less susceptible to ampicillin. Among the antimicrobials tested, ceftizoxim was the most active against H. influenzae in both countries (MICs 〓0.2 ugml^<-1>). Five strains of S. pneumoniae in Japan were relatively resistant to ampicillin (MIC=0.1 ugml^<-1>), whereas there were no such strains among isolates in the Philippines. Forty strains (22.3%) and 108 strains (60.3%) among S. pneumoniae in Japan exhibited erythromycin MICs 〓0.2 ugml^<-1> and minocycline MICs 〓1.56 ugml^<-1>, respectively. In contrast, all isolates in the Philippines were erythromycin MICs 〓0.05 ugml^<-1> and minocycline MICs 〓0.39 ugml^<-1>. Present study indicates that H. influenzae and S. pneumoniae in the Philippines remained still susceptible to the antimicrobials tested except for 2 β-lactamase-positive, ampicillin-resistant H. influenzae, whereas ampicillin-resistant H. influenzae mediated by β-lactamase or non-β-lactamase mechanisms and ampicillin-, erythromycin- or minocycline-resistant S. pneumoniae were included among isolates in Japan.
URI: http://hdl.handle.net/10069/4622
ISSN: 03855643
資料タイプ: Departmental Bulletin Paper
出現コレクション:第35巻 第2号

引用URI : http://hdl.handle.net/10069/4622

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