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Functional Antigenic Molecules of Different Life-Stages of Rodent Filariid, Acanthocheilonema viteae and Their Cross Reactivity with Human Filarial (Wuchereria bancrofti) Sera.


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タイトル: Functional Antigenic Molecules of Different Life-Stages of Rodent Filariid, Acanthocheilonema viteae and Their Cross Reactivity with Human Filarial (Wuchereria bancrofti) Sera.
著者: Misra, Shailja / Singh, D.P. / Dikshit, Manisha / Chatterjee, R.K.
発行日: 1994年 6月30日
出版者: 長崎大学熱帯医学研究所 / Institute of Tropical Medicine, Nagasaki University
引用: 熱帯医学 Tropical medicine 36(1). p35-42, 1994
抄録: Proteins obtained by SDS-solubilisation of various developmental stages (adults, uterus contents, microfilariae and infective larvae) of the filariid Acanthocheilonema viteae were separated by SDS-polyacrylamide gel electrophoresis (SDS-PAGE) and electrophoretically transferred onto nitrocellulose filter sheets. The results showed minor differences in the protein pattern of adult worms, microfilariae, uterine contents and infective larvae. Immunoperoxidase staining of these antigens with infected mastomys sera showed that maximum number of antigens in infective larval stage were identified by the sera collected at prepatent stage of infection whereas in adult antigen maximum bands were recognized by sera from patent infection. A large number of microfilarial antigens were found to be immunoreactive during patent stage but only a few remained functional during latency. Uterine antigens possess a number of immunoreactive components which reacted with antibodies in sera of all stages of infection with maximum recognition by patent (microfilaraemic) serum. Cross reaction between A. viteae antigen and W. bancrofti human sera led to identification of a few common molecules which demonstrated the usefulness of antigens of rodent filariid A. viteae in immunodiagnosis or in evolving strategies for vaccination against human filariasis.
URI: http://hdl.handle.net/10069/4669
ISSN: 03855643
資料タイプ: Departmental Bulletin Paper
出現コレクション:第36巻 第1号

引用URI : http://hdl.handle.net/10069/4669

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