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NAOSITE : Nagasaki University's Academic Output SITE > Institute of Tropical Medicine > Bulletin > Tropical medicine > Volume 36, No. 2 >

Brown Adipose Tissue in Amyotrophic Lateral Sclerosis


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Title: Brown Adipose Tissue in Amyotrophic Lateral Sclerosis
Authors: Ito, Masahiro / Matsuzaki, Sumihiro / Yamaguchi, Eiichiro / Nakashima, Masahiro / Nakayama, Toshiyuki / Naito, Shinji / Sekine, Ichiro
Issue Date: 30-Oct-1994
Publisher: 長崎大学熱帯医学研究所 / Institute of Tropical Medicine, Nagasaki University
Citation: 熱帯医学 Tropical medicine 36(2). p43-49, 1994
Abstract: The prevalence of brown adipose tissue (BAT) in the periadrenal adipose tissue was studied in 20 autopsy cases of amyotrophic lateral sclerosis (ALS). In 19 of 20 cases, the periadrenal BAT in focal or diffuse distribution was observed. Histometry of BAT revealed average occupancy rates of 21.6% and 4.2% in ALS and age-matched control cases, respectively (p<0.01). Since emaciation and chronic hypoxia in those ALS patients were most likely related to severe muscle wasting and respiratory involvement, it is speculated that an increase in BAT occupancy rates may be secondary to altered thermogenesis which was augmented by chronic hypoxia.
URI: http://hdl.handle.net/10069/4670
ISSN: 03855643
Type: Departmental Bulletin Paper
Appears in Collections:Volume 36, No. 2

Citable URI : http://hdl.handle.net/10069/4670

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