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Progressive Multifocal Leukoencephalopathy (PML) in A Japanese Patient with Acquired Immunodeficiency Syndrome (AIDS) : A Case Report


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タイトル: Progressive Multifocal Leukoencephalopathy (PML) in A Japanese Patient with Acquired Immunodeficiency Syndrome (AIDS) : A Case Report
著者: Mwinyimtwana, Ahmed Makata / Toriyama, Kan / Itakura, Hideyo / Momita, Saburo
発行日: 1994年10月30日
出版者: 長崎大学熱帯医学研究所 / Institute of Tropical Medicine, Nagasaki University
引用: 熱帯医学 Tropical medicine 36(2). p57-64, 1994
抄録: We report an autopsy case of progressive multifocal leukoencephalopathy (PML) of a 40 year-old Japanese male with acquired immunodeficiency syndrome (AIDS). Since he was diagnosed as hemophilia A at the age of 15 years, he had been treated with factor VIII concentrates. When he was 35 years old, the antibody against human immunodeficiency virus (HIV) was found to be positive. Four years later he was pointed out left hemiparesis. Pneumocystis carinii organisms were detected and he was diagnosed as AIDS at the age of 40 years. During his admission multiple lesions were demonstrated in the cerebral white matter by MRI and CT scan and suspected to be PML. Dyspnea aggravated rapidly and he died from respiratory failure. Autopsy examination revealed multiple necrotic foci in the cerebral white matter, which showed characteristic histological features to be confirmed as PML, namely, multiple demyelinating foci with enalrged and bizarre astrocytes, hypertrophied oligodendrocytes with intranuclear inclusion bodies and numerous lipid-laden macrophages.
URI: http://hdl.handle.net/10069/4672
ISSN: 03855643
資料タイプ: Departmental Bulletin Paper
出現コレクション:第36巻 第2号

引用URI : http://hdl.handle.net/10069/4672

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