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HEPATITIS C VIRUS AND ITS GENE STRUCTURE AND FUNCTION


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タイトル: HEPATITIS C VIRUS AND ITS GENE STRUCTURE AND FUNCTION
著者: Ali, Ayub / Hasebe, Futoshi / Morita, Kouichi / Igarashi, Akira
発行日: 1995年 8月31日
出版者: 長崎大学熱帯医学研究所 / Institute of Tropical Medicine, Nagasaki University
引用: 熱帯医学 Tropical medicine 37(2). p39-64, 1995
抄録: Hepatitis C virus (HCV) is a member of the family Flaviviridae, and the principal cause of parenteral non A non B hepatitis. HCV is a single stranded, positive sense RNA virus whose genome contains a single open reading frame of about 10 kb in length which encodes a polyprotein of about 3000 amino acids. HCV is responsible for majority of the transfusion associated cases of hepatitis and a significant proportion of community-acquired hepatitis which leads to a range of clinical manifestations from an apparent carrier state to severe chronic hepatitis, liver cirrhosis and hepatocellular carcinoma. Cell-free translation and cell culture transient expression studies revealed that HCV genome initially transcribed as a polyprotein is processed by cellular and viral proteases to produce the putative viral structural and nonstructural proteins. The preliminary map of the gene order for HCV was established: 5' untranslated region (UTR)-core (C)-envelope 1 (E1)-E2-nonstructural 2(NS2)-NS3-NS4A-NS4B-NS5A-NS5B-UTR3'. Nonstructural proteins, NS2, NS3 and NS5, are believed to be a component of viral coded enzymes. Mutations in hypervariable region 1 (HVR1) of the E2 protein was considered to be a possible mechanism of chronicity of HCV infection. HCV infection can be monitored either by serodiagnosis or by genodiagnosis. Interferon seems to be considered as the sole drug for HCV treatment until now. In the history of virology, HCV was the first example that was identified by molecular cloning of its genome from infectious materials.
URI: http://hdl.handle.net/10069/4703
ISSN: 03855643
資料タイプ: Departmental Bulletin Paper
出現コレクション:第37巻 第2号

引用URI : http://hdl.handle.net/10069/4703

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