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Genotype Determination of Hepatitis C Virus Strains in Malaysia


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Title: Genotype Determination of Hepatitis C Virus Strains in Malaysia
Authors: Zheng, Wei-Yun / Hasebe, Futoshi / Ali, Ayub / Sinniah, Mangalam / Saraswathy, T. S. / Ooi, Beng Geok / Igarashi, Akira
Issue Date: 30-Jun-1996
Publisher: 長崎大学熱帯医学研究所 / Institute of Tropical Medicine, Nagasaki University
Citation: 熱帯医学 Tropical medicine 38(2). p51-60, 1996
Abstract: Out of 12 patient sera obtained from Malaysia, seven sera (7/12) were found to contain hepatitis C virus (HCV) genome by nested RT-PCR with universal HCV specific primers which were derived from 5' noncoding region (5' NCR). Genotype determination of these 7 Malaysian HCV strains were carried out both by subtype-specific core amplification system (Okamoto et al., 1992 and 1993) and sequencing in the 5' NCR. Four Malaysian strains were major genotype 1 (two of subtype II/1b, one of subtype I/1a and one of co-infection with I/1a + II/1b). The genotypes of 3 remaining strains were determined as major genotype 3 by nucleotide sequences in the 5' NCR. The results showed that HCV major genotype 1, 2 and 3 are common in the world, especially in Asian countries including Malaysia.
URI: http://hdl.handle.net/10069/4725
ISSN: 03855643
Type: Departmental Bulletin Paper
Appears in Collections:Volume 38, No. 2

Citable URI : http://hdl.handle.net/10069/4725

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