DSpace university logo mark
Japanese | English 

NAOSITE : Nagasaki University's Academic Output SITE > 120 熱帯医学研究所 > 120 紀要 > 熱帯医学 > 第40巻 第1号 >

Effects of Incremental Doses of Chloroquine Phosphate on the Formed Elements of Blood.

ファイル 記述 サイズフォーマット
tm40_01_01_t.pdf545.58 kBAdobe PDF本文ファイル

タイトル: Effects of Incremental Doses of Chloroquine Phosphate on the Formed Elements of Blood.
著者: Othman, Timothy / Arowolo, R. O. A.
発行日: 1998年 9月10日
出版者: 長崎大学熱帯医学研究所 / Institute of Tropical Medicine, Nagasaki University
引用: 熱帯医学 Tropical medicine 40(1). p1-7, 1998
抄録: Easy access to chloroquine (CQ) in many developing countries can result to intake of inappropriate doses. This study was therefore conducted to evaluate the acute effects of high doses of CQ on hematological parameters and plasma Na+and K+ concentrations. To do this, Swiss albino rats were administered incremental doses of CQ intraperitoneally at dose rates ranging between 0.5 to 8mg/kg b.wt. Two hours later, blood samples were taken and analysed. 8mg/kg b.wt of CQ induced significant decrease in red blood cells (RBC), hemoglobin (Hb) and significant increase in mean corpuscular volume (MCV). There was a significant increase in white blood cell count at all dose levels. Packed cell volume (PCV), mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC) were not affected by all dose ranges. There was significant increase in plasma Na+ and K+ by dose rates of 4 and 8 mg/kg but not by lower doses. These data indicate that most CQ induced toxicities on the formed elements of blood occurs at doses greater than 4 times the standard therapeutic dose in rats.
URI: http://hdl.handle.net/10069/4750
ISSN: 03855643
資料タイプ: Departmental Bulletin Paper
出現コレクション:第40巻 第1号

引用URI : http://hdl.handle.net/10069/4750



Valid XHTML 1.0! Copyright © 2006-2015 長崎大学附属図書館 - お問い合わせ Powerd by DSpace