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A Simple Method for Screening of Macrofilaricidal Compounds-The Inhibitory Effect of Substances on Phosphatase Activity of Adult Dirofilaria immitis


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Title: A Simple Method for Screening of Macrofilaricidal Compounds-The Inhibitory Effect of Substances on Phosphatase Activity of Adult Dirofilaria immitis
Authors: Maki, Jun / Kuwata, Masahiro / Mitsui, Yoshinori / Fujimaki, Yasunori / Ito, Yoichi
Issue Date: 30-Oct-1998
Publisher: 長崎大学熱帯医学研究所 / Institute of Tropical Medicine, Nagasaki University
Citation: 熱帯医学 Tropical medicine 40(2). p95-97, 1998
Abstract: A simple and reproducible screening method of macrofilaricides is described. The method evaluated in the present paper is based on inhibitory activity of the drugs on acid-phosphatase of Dirofilaria immitis adult worms. The potent inhibitor of acid-phosphates, NaF, inhibited completely the enzymic activity at 1 mM. trimelarsan, suramin and flubendazole inhibited partially the enzymic activity. Their inhibitory activity is comparable to that of Na_2HAsO_4, a specific inhibitor of phosphatase. Diethylcarbamazine and levamisole did not inhibit the phosphatase of D. immitis.
URI: http://hdl.handle.net/10069/4755
ISSN: 03855643
Type: Departmental Bulletin Paper
Appears in Collections:Volume 40, No. 2

Citable URI : http://hdl.handle.net/10069/4755

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