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THE EFFECT OF MEDICATION ON QUESTIONNAIRE ANALYSIS OF CHILDREN WITH SCHISTOSOMA MANSONI INFECTION IN TANZANIA


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タイトル: THE EFFECT OF MEDICATION ON QUESTIONNAIRE ANALYSIS OF CHILDREN WITH SCHISTOSOMA MANSONI INFECTION IN TANZANIA
著者: Kisu, Tomoko / Shiratori, Kiyoshi / francis callyst / Ataka, Yuji / Kaneda, Eiko / elisonguo ngomuo / richard j. shayo / Shimada, Masaaki
発行日: 2005年12月
出版者: 日本熱帯医学会 / The Japanese Society of Tropical Medicine
引用: Tropical Medicine and Health Vol. 33 No. 3, 2005, pp. 143-152
抄録: The effect of mass treatment on questionnaire results in the diagnosis of schistosomiasis mansoni was examined in 267 school children in an endemic area of Tanzania by Kato-Katz analysis of fecal specimens. The questionnaire asked for information about self-diagnosis, abdominal symptoms, blood in stools, history of wild water contact, stool examination and medication for schistosomiasis, and knowledge of the disease. A logistic regression analysis disclosed a significant association between schistosomiasis and diarrhea (p ? 0.007; odds ratio, 32.0; confidence interval, 2.5 - 403.3) and abdominal enlargement (p ? 0.003; odds ratio, 15.2; confidence interval, 2.6 - 90.1) among 61 children who had no history of medication for schistosomiasis. The sensitivity and specificity of the model were 86% and 64%, respectively. In contrast, no significant correlation was observed either for the 116 treated children, or for all the 267 children after the mass treatment. We conclude, therefore, that for children who had no history of medication for schistosomiasis, the questionnaire for abdominal manifestations provides reliable information on S. mansoni infection. However, once a child takes medication, the questionnaire becomes unreliable. This observation suggests that immunomodulation by anti-schistosomiasis drugs that kill adult worms exerts an effect on the appearance of abdominal manifestations and might explain the ambiguity of clinical symptoms in chronically infested patients, except in terminal cases. Further studies are required to develop a simple, rapid and cost-effective diagnostic method for monitoring S. mansoni infection after medication in local areas without resort to laboratory-based identification of schistosomiasis.
キーワード: Schistosoma mansoni / self-diagnosis / selective mass treatment / Tanzania
URI: http://hdl.handle.net/10069/5665
ISSN: 13488945
関連リンク : http://www.jstage.jst.go.jp/article/tmh/33/3/143/_pdf/-char/ja/
権利: Copyright(c) 2005 by The Japanese Society of Tropical Medicine
資料タイプ: Journal Article
原稿種類: publisher
出現コレクション:120 学術雑誌論文

引用URI : http://hdl.handle.net/10069/5665

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