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Absorption characteristics of dextrans with different molecular weights from the liver surface membrane in rats: implications for targeting to the liver


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タイトル: Absorption characteristics of dextrans with different molecular weights from the liver surface membrane in rats: implications for targeting to the liver
著者: Nishida, Koyo / Sato, Norihito / Sasaki, Hitoshi / Nakamura, Junzo
発行日: 1996年
出版者: Taylor & Francis
引用: Journal of Drug Targeting, 4 (3), 141-150, 1996
抄録: We examined the importance of molecular weight on the absorption from the liver surface in rats using fluorescein isothiocyanate-dextrans (FDs) with molecular weights of 4,400 (FD-4), 9,300 (FD-10), 40,500 (FD-40) or 69,000 (FD-70). After application of FDs (5 mg) to the rat liver surface employing a cylindrical glass cell (i.d. 9 mm), each FD appeared gradually in the plasma, and the in vivo behavior was explained by two-compartment model with first-order absorption. The absorption ratios of FDs from the rat liver surface at 6 h, calculated from the amount recovered from the glass cell, decreased with an increase in the molecular weight (44.5% for FD-4, 29.3% for FD-10, 5.1% for FD-40 and 2.2% for FD-70). A linear relationship was observed between the absorption rate constant and the reciprocal value with square root of molecular weight of the model compounds. The limit of absorption from the rat liver surface was extrapolated to be at a molecular weight of 70,000. Furthermore, absorbed FDs were accumulated in the liver, as high liver/plasma concentration ratio as compared with that of i.v. administration. We clarified the molecular weight dependence of drug absorption from the liver surface in rats. Moreover, the liver surface application appeared to be a promising route with enhancing the efficacy of drug targeting to the liver.
記述: without figures / グラフなし
URI: http://hdl.handle.net/10069/6487
ISSN: 1061186X
DOI: 10.3109/10611869609015971
PubMed ID: 8959486
権利: This is an electronic version of an article published in Journal of Drug Targeting, 4 (3), 141-150, 1996. the Journal of Drug Targeting is available online at: http://www.informaworld.com/openurl?genre=article&issn=1061-186X&volume=4&issue=3&spage=141.
資料タイプ: Journal Article
原稿種類: author
出現コレクション:050 学術雑誌論文

引用URI : http://hdl.handle.net/10069/6487

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