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Absorption of organic anions as model drugs following application to rat liver surface in-vivo


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Title: Absorption of organic anions as model drugs following application to rat liver surface in-vivo
Authors: Nishida, Koyo / Sato, Norihito / Sasaki, Hitoshi / Nakamura, Junzo
Issue Date: Nov-1994
Publisher: Pharmaceutical Press
Citation: Journal of Pharmacy and Pharmacology, 46 (11), 867-870, 1994
Abstract: Absorption of organic anions (phenol red, bromphenol blue and bromosulphonphthalein) has been studied after their application to rat liver surface in-vivo, employing a cylindrical glass cell (i.d. 9 mm, area 0.64 cm2). Every drug appeared gradually in the blood with the peak level at about 1 h, after which its concentration declined slowly. Absorbed model drug was efficiently excreted into the bile. These observations appear to indicate the possibility of drug absorption from liver surface membrane. Absorption ratios of model drugs were estimated to be more than 59 % in 6 h. As to phenol red, its biliary recovery and metabolism ratio did not change as compared with that of i.v. administration.
Description: without figures / グラフなし
URI: http://hdl.handle.net/10069/6671
ISSN: 00223573
PubMed ID: 7897589
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/6671

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