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Absorption of organic anions as model drugs following application to rat liver surface in-vivo


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タイトル: Absorption of organic anions as model drugs following application to rat liver surface in-vivo
著者: Nishida, Koyo / Sato, Norihito / Sasaki, Hitoshi / Nakamura, Junzo
発行日: 1994年11月
出版者: Pharmaceutical Press
引用: Journal of Pharmacy and Pharmacology, 46 (11), 867-870, 1994
抄録: Absorption of organic anions (phenol red, bromphenol blue and bromosulphonphthalein) has been studied after their application to rat liver surface in-vivo, employing a cylindrical glass cell (i.d. 9 mm, area 0.64 cm2). Every drug appeared gradually in the blood with the peak level at about 1 h, after which its concentration declined slowly. Absorbed model drug was efficiently excreted into the bile. These observations appear to indicate the possibility of drug absorption from liver surface membrane. Absorption ratios of model drugs were estimated to be more than 59 % in 6 h. As to phenol red, its biliary recovery and metabolism ratio did not change as compared with that of i.v. administration.
記述: without figures / グラフなし
URI: http://hdl.handle.net/10069/6671
ISSN: 00223573
PubMed ID: 7897589
資料タイプ: Journal Article
原稿種類: author
出現コレクション:050 学術雑誌論文

引用URI : http://hdl.handle.net/10069/6671

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