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Absorption of phenol red and bromphenol blue as model drugs from the peritoneal cavity around the liver surface in rats


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Title: Absorption of phenol red and bromphenol blue as model drugs from the peritoneal cavity around the liver surface in rats
Authors: Nishida, Koyo / Sato, Norihito / Sasaki, Hitoshi / Nakamura, Junzo
Issue Date: Dec-1995
Publisher: Pharmaceutical Press
Citation: Journal of Pharmacy and Pharmacology, 47 (12A), 1032-1035, 1995
Abstract: The effect of the injection site on the pharmacokinetics of phenol red and bromphenol blue as model drugs after intraperitoneal (i.p.) administration into rats was examined. Their absorption rate from the peritoneal cavity was faster after i.p. administration to the liver surface (LS) than that after i.p. administration to the distal small intestine (SI), as shown by the increase in maximum concentration and decrease in mean residence time in plasma. A similar tendency was observed in the biliary excretion pattern. The enhanced absorption rate was supported by the significantly smaller amount of both drugs remaining in the peritoneal cavity at 15 min after LS administration than that after SI administration. The liver concentration of the model drugs at 15 min after LS administration was 1.5 - 2.0 times higher than that after SI administration. Accordingly, LS administration was shown to be effective with good absorbability and efficient drug delivery to the liver.
Description: without figures / グラフなし
URI: http://hdl.handle.net/10069/6672
ISSN: 00223573
PubMed ID: 8932690
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/6672

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