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Absorption characteristics of model compounds with different molecular weights from the serosal caecal surface in rats


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Title: Absorption characteristics of model compounds with different molecular weights from the serosal caecal surface in rats
Authors: Nishida, Koyo / Nose, Seiichi / Kuma, Akiko / Mukai, Takahiro / Kawakami, Shigeru / Nakashima, Mikiro / Sasaki, Hitoshi / Toshiyuki, Sakaeda / Nakamura, Junzo
Issue Date: Jul-2002
Publisher: Pharmaceutical Press
Citation: Journal of Pharmacy and Pharmacology, 54 (7), 1005-1009, 2002
Abstract: The purpose of this study is to clarify the absorption characteristics of drugs across the serosal cecal surface membrane occupying a large absorption area in the peritoneal cavity in rats. Absorptions of phenolsulphonphthalein (PSP) and fluorescein isothiocyanate-dextrans (FDs) as model drugs after application to the rat serosal cecal surface were investigated in rats, employing a cylindrical diffusion cell. PSP was absorbed from the rat serosal cecal surface, followed by appearance in the plasma and bile. The time course of the remaining PSP amount in the diffusion cell obeyed first-order kinetics, and its rate constant Ka was calculated to be 8.01 x 10-3 min-1. No significant difference was seen in the absorption ratio of PSP which was approximately 90 % in 6 h among three doses (0.3, 0.5 and 1 mg), suggesting a linearity of absorption. Moreover, the absorption ratios of FDs from the rat serosal cecal surface at 3 h decreased with an increase in the molecular weight (24.7% for FD-4, 12.8% for FD-10 and 3.4% for FD-40).
URI: http://hdl.handle.net/10069/6676
ISSN: 00223573
PubMed ID: 12162704
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/6676

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