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Absorption characteristics of model compounds from the small intestinal serosal surface and a comparison with other organ surfaces


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Title: Absorption characteristics of model compounds from the small intestinal serosal surface and a comparison with other organ surfaces
Authors: Nishida, Koyo / Kuma, Akiko / Fumoto, Shintaro / Nakashima, Mikiro / Sasaki, Hitoshi / Nakamura, Junzo
Issue Date: Aug-2005
Publisher: Pharmaceutical Press
Citation: Journal of Pharmacy and Pharmacology, 57 (8), 1073-1077, 2005
Abstract: We examined the absorption of phenolsulfonphthalein (PSP) and fluorescein isothiocyanate dextrans (FD-4, MW 4,400; FD-10, MW 9,500; FD-40, MW 40,500) as model compounds through the small intestinal serosal surface. After application to the rat small intestinal serosal surface using a cylindrical diffusion cell, each compound was absorbed at different rates. The absorption ratios in 6 h after PSP, FD-4, FD-10 and FD-40 application were calculated to be 89.2, 34.6, 14.9 and 2.1 % of dose, respectively. Elimination profiles of PSP, FD-4 and FD-10 from the small intestinal serosal surface obeyed first-order kinetics. Moreover, we calculated the apparent permeability coefficient Papp for comparison to other organ surfaces. The kidney had the highest absorption efficiency, as shown by having more than 1.5 times significantly higher Papp values of PSP, FD-4 and FD-10. Similar to the other organ surfaces, a correlation was observed between the Papp of small intestine and the molecular weight of these hydrophilic compounds. In addition, the small intestine is likely to contribute largely to hydrophilic compounds absorption from the peritoneal cavity, judging from absorption clearance CLa calculated by utilizing the peritoneal organ surface area.
URI: http://hdl.handle.net/10069/6678
ISSN: 00223573
PubMed ID: 16102265
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/6678

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