DSpace university logo mark
詳細検索
Japanese | English 

NAOSITE : Nagasaki University's Academic Output SITE > 050 薬学部 > 050 学術雑誌論文 >

Absorption characteristics of model compounds from the small intestinal serosal surface and a comparison with other organ surfaces


ファイル 記述 サイズフォーマット
JPP57_1073.pdf135.52 kBAdobe PDF本文ファイル

タイトル: Absorption characteristics of model compounds from the small intestinal serosal surface and a comparison with other organ surfaces
著者: Nishida, Koyo / Kuma, Akiko / Fumoto, Shintaro / Nakashima, Mikiro / Sasaki, Hitoshi / Nakamura, Junzo
発行日: 2005年 8月
出版者: Pharmaceutical Press
引用: Journal of Pharmacy and Pharmacology, 57 (8), 1073-1077, 2005
抄録: We examined the absorption of phenolsulfonphthalein (PSP) and fluorescein isothiocyanate dextrans (FD-4, MW 4,400; FD-10, MW 9,500; FD-40, MW 40,500) as model compounds through the small intestinal serosal surface. After application to the rat small intestinal serosal surface using a cylindrical diffusion cell, each compound was absorbed at different rates. The absorption ratios in 6 h after PSP, FD-4, FD-10 and FD-40 application were calculated to be 89.2, 34.6, 14.9 and 2.1 % of dose, respectively. Elimination profiles of PSP, FD-4 and FD-10 from the small intestinal serosal surface obeyed first-order kinetics. Moreover, we calculated the apparent permeability coefficient Papp for comparison to other organ surfaces. The kidney had the highest absorption efficiency, as shown by having more than 1.5 times significantly higher Papp values of PSP, FD-4 and FD-10. Similar to the other organ surfaces, a correlation was observed between the Papp of small intestine and the molecular weight of these hydrophilic compounds. In addition, the small intestine is likely to contribute largely to hydrophilic compounds absorption from the peritoneal cavity, judging from absorption clearance CLa calculated by utilizing the peritoneal organ surface area.
URI: http://hdl.handle.net/10069/6678
ISSN: 00223573
PubMed ID: 16102265
資料タイプ: Journal Article
原稿種類: author
出現コレクション:050 学術雑誌論文

引用URI : http://hdl.handle.net/10069/6678

このリポジトリに保管されている文献はすべて著作権により保護されています。
印刷やダウンロード等データの複製は、調査研究・教育または学習を目的とする場合に限定されます。

 

Valid XHTML 1.0! Copyright © 2006-2015 長崎大学附属図書館 - お問い合わせ Powerd by DSpace