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Effect of albumin on the absorption of phenol red, bromphenol blue and bromosulphonphthalein as model drugs from the liver surface membrane in rats,


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タイトル: Effect of albumin on the absorption of phenol red, bromphenol blue and bromosulphonphthalein as model drugs from the liver surface membrane in rats,
著者: Nishida, Koyo / Sato, Norihito / Sasaki, Hitoshi / Nakamura, Junzo
発行日: 1995年11月
出版者: 日本薬学会 / The Pharmaceutical Society of Japan
引用: Biological & Pharmaceutical Bulletin, 18 (11), p.1548-1550, 1995
抄録: The effect of bovine serum albumin (BSA) on drug absorption from the liver surface in rats was examined by using three organic anions (phenol red, bromphenol blue and bromosulphonphthalein) as model drugs which have a high affinity for albumin. The binding ratio of the model drugs (3 mg/ml in phosphate buffer) to BSA varied widely at a BSA concentration of 0.1--10% (w/v). The model drugs (3 mg/ml x 0.1 ml) with or without BSA were applied to the rat liver surface in vivo employing a cylindrical glass cell (i.d. 9 mm, area 0.64 cm2). The absorption ratios of the model drugs from the rat liver surface at 6h, calculated from the amount recovered from the glass cell, decreased with an increase in BSA concentration. A similar trend was observed with biliary recovery of the model drugs. A marked reduction in the absorption ratio was seen with bromosulphonphthalein, which has the highest binding activity to BSA among the three organic anions. Accordingly, protein binding appears to be a significant factor with respect to the drug absorption from the liver surface.
記述: グラフなし / without graphs
キーワード: protein binding / absorption / liver surface / rat / organic anion / bovine serum albumin
URI: http://hdl.handle.net/10069/6679
ISSN: 09186158
PubMed ID: 8593477
権利: Copyright (c) 1995 The Pharmaceutical Society of Japan
資料タイプ: Journal Article
原稿種類: author
出現コレクション:050 学術雑誌論文

引用URI : http://hdl.handle.net/10069/6679

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