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Development of Plasma Vitellogenin Assay for Estrogenic Effects of Endocrine-Disrupting Chemicals Using Ovariectomized Goldfish (Carassius auratus)


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タイトル: Development of Plasma Vitellogenin Assay for Estrogenic Effects of Endocrine-Disrupting Chemicals Using Ovariectomized Goldfish (Carassius auratus)
著者: Ishibashi, Hiroshi / Kobayashi, Makito / Tomiyasu, Yuki / Miyahara, Maki / Tachibana, Katsuyasu / Tsuchimoto, Mutsuyosi / Arizono, Koji
発行日: 2004年 4月
出版者: Pharmaceutical Society of Japan.
引用: Journal of Health Science v.50(2) p.169-173, 2004
抄録: Plasma vitellogenin (VTG) assay was developed using ovariectomized goldfish (Carassius auratus) for determining the estrogenic effects of endocrine-disrupting chemicals. In a laboratory study, we assessed the estrogenic activity of commercial fish diets by using a diet for ornamental carp (CD) and a casein-based formulated fish diet (FD), which was shown to not contain soybean or fish meal in a previous study. In ovariectomized fish, plasma VTG concentrations were significantly higher in the CD-fed group than in the FD-fed group. These results indicate that the estrogen activity of CD may be high enough to cause induction of plasma VTG in ovariectomized goldfish as previously observed in male goldfish. Moreover, the effect of estrogen on plasma VTG induction was confirmed by significant plasma VTG production following the exposure of FD-fed ovariectomized goldfish to a nominal estradiol-17β concentration of 100 μg/l for 31 days. Our data suggest that induction of plasma VTG using ovariectomized goldfish is a good tool for evaluating the estrogenic effects of endocrine-disrupting chemicals.
キーワード: ovariectomized goldfish / vitellogenin / estrogenic effect / phytoestrogen
URI: http://hdl.handle.net/10069/8335
ISSN: 13449702
DOI: 10.1248/jhs.50.169
関連リンク : http://dx.doi.org/10.1248/jhs.50.169
資料タイプ: Journal Article
原稿種類: publisher
出現コレクション:080 学術雑誌論文

引用URI : http://hdl.handle.net/10069/8335

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