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Antimicrobial Activity of Saturated Fatty Acids and Fatty Amines against Methicillin-Resistant Staphylococcus aureus

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タイトル: Antimicrobial Activity of Saturated Fatty Acids and Fatty Amines against Methicillin-Resistant Staphylococcus aureus
著者: Kitahara, Takashi / Koyama, Nao / Matsuda, Junichi / Aoyama, Yuko / Hirakata, Yoichi / Kamihira, Shimeru / Kohno, Shigeru / Nakashima, Mikiro / Sasaki, Hitoshi
発行日: 2004年 9月
出版者: Pharmaceutical Society of Japan
引用: Biological & Pharmaceutical Bulletin v.27(9) p.1321-1326, 2004
抄録: The objective of this study was to investigate the antimicrobial activities of saturated fatty acids and fatty amines against methicillin-resistant Staphylococcus aureus (MRSA). The antimicrobial activity of saturated fatty acids and fatty amines was determined by oxygen meters with multi-channels and disposable oxygen electrode sensors (DOX-96). Lauric acid, the most effective among the saturated fatty acids, showed antimicrobial activity at 400 μg/ml against methicillin-susceptible Staphylococcus aureus (MSSA) and MRSA. The minimal inhibitory concentration (MIC) of fatty amines depended on each hydrophobic chain length. The MIC of myristylamine was 1.56 μg/ml; most effective of the fatty amines. In time-kill curves, lauric acid and myristylamine produced a bactericidal effect and a bacteriostatic effect at 4-fold the MIC, respectively. The antimicrobial activities of lauric acid and myristylamine were decreased by human plasma. Cytotoxicity of 3 saturated fatty acids and 3 fatty amines was examined in cultured endothelial cells. Although cytotoxicity of fatty amines was severer than that of saturated fatty acids, myristylamine showed the highest value of apparent therapeutic index among them. DOX-96 was useful for screening antimicrobial substances, especially in the case of insoluble substances. We found that myristylamine showed anti-MRSA activity comparable to that of vancomycin and teicoplanin.
キーワード: methicillin-resistant Staphylococcus aureus (MRSA) / oxygen meter / fatty acid / fatty amine / antimicrobial activity
URI: http://hdl.handle.net/10069/8341
ISSN: 09186158
DOI: 10.1248/bpb.27.1321
PubMed ID: 15340213
関連リンク : http://dx.doi.org/10.1248/bpb.27.1321
資料タイプ: Journal Article
原稿種類: publisher
出現コレクション:130 学術雑誌論文

引用URI : http://hdl.handle.net/10069/8341



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