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Title: 長崎大学医学部・歯学部附属病院における整腸剤適正使用への取り組み
Other Titles: Investigation for Proper Use of Probiotics in Nagasaki University Hospital pf Medicine and Density
Authors: 江頭, かの子 / 北原, 隆志 / 柏木, 香 / 樋口, 則英 / 中嶋, 幹郎 / 一川, 暢宏 / 佐々木, 均
Authors (alternative): Egashira, Kanoko / Kitahara, Takashi / Kashiwagi, Kaoru / Higuchi, Norihide / Nakashima, Mikiro / Ichikawa, Nobuhiro / Sasaki, Hitoshi
Issue Date: Nov-2006
Publisher: 日本薬学会
Citation: YAKUGAKU ZASSHI v.126(11) p.1155-1161, 2006
Abstract: Antimicrobial agents sometimes cause the adverse effects of diarrhea and loose stool. Antibiotic-resistant lactic acid bacteria are used to prevent these adverse effects. The bacteria are not resistant to several antimicrobial agents, although the bacterium preparations are sometimes prescribed the antimicrobial agents concomitantly. Therefore this paper reports that the minimal inhibitory concentration of three new antimicrobial agents against antibiotic-resistant lactic acid bacteria were determined using a microdilution method with cation-adjusted Mueller-Hinton broth. Furthermore, we investigated antimicrobial agents that are prescribed concomitantly with antibiotic-resistant lactic acid bacterium preparations or a clostridium butyricum preparation. The bacteria were susceptible to the three new antimicrobial agents. Approximately 50% of the bacterium preparations were prescribed alone, and 30% were prescribed concomitantly with antimicrobial agents that show antimicrobial activity against the bacteria. Consequently, we suggest that pharmacists need to confirm prescriptions and to provide more drug information on antibiotic-resistant lactic acid bacterium preparations.
Keywords: antibiotic-resistant lactic acid bacteria / clostridium butyricum / diarrhea / antimicrobial agents / drug information
URI: http://hdl.handle.net/10069/8345
ISSN: 00316903
DOI: 10.1248/yakushi.126.1155
PubMed ID: 17077616
Relational Links: http://dx.doi.org/10.1248/yakushi.126.1155
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/8345

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