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A Convenient Sublethal Assay of Alkylphenol and Organotin Compounds Using the Nematode Caenorhabditis elegans


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タイトル: A Convenient Sublethal Assay of Alkylphenol and Organotin Compounds Using the Nematode Caenorhabditis elegans
著者: Tominaga, Nobuaki / Tomoeda, Mineko / Kohra, Shinya / Takao, Yuji / Nagae, Masaki / Ueda, Kazuo / Ishibashi, Yasuhiro / Kai, Toshinori / Arizono, Koji
発行日: 2002年12月
出版者: Pharmaceutical Society of Japan
引用: Journal of Health Science v.48(6) p.555-559, 2002
抄録: The free-living nematode, Caenorhabditis elegans (C. elegans) was adopted as a multicellular biosensor of biological toxicity from alkylphenols and organotin compounds. Alkylphenols were found to affect reproduction at lower doses than indicated by the acute toxicity assay. In particular, nonylphenol altered the reproduction rate of C. elegans at a dose 10- to 100-fold lower than the 50% lethal concentration (LC50). A comparison of the number of viable worms and eggs suggested that alkylphenols and organotin compounds possess hatching toxicity. A 0.1 μM dose of organotin compounds caused a significant decrease, in the order of 20-50%, in reproduction of the worms, and an abnormal male: hermaphrodite ratio was observed. C. elegans therefore appears to represent a potent and sensitive organism with which to evaluate the biological effects of chemicals. In particular, the sensitivity of reproduction as an endpoint is highly useful for assessing the sublethal effects of chemicals.
キーワード: Caenorhabditis elegans / reproduction / fecundity / hatching rate / male expression / biosensor
URI: http://hdl.handle.net/10069/8364
ISSN: 13449702
DOI: 10.1248/jhs.48.555
関連リンク : http://dx.doi.org/10.1248/jhs.48.555
資料タイプ: Journal Article
原稿種類: publisher
出現コレクション:070 学術雑誌論文

引用URI : http://hdl.handle.net/10069/8364

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