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Estrogenic Potency of a Bisphenol A Metabolite on Vitellogenin Synthesis in Medaka, Oryzias latipes


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Title: Estrogenic Potency of a Bisphenol A Metabolite on Vitellogenin Synthesis in Medaka, Oryzias latipes
Authors: Nagae, Masaki / Shiroyama, Ken'Ichirou / Inoue, Mihoka / Hara, Akihiko / Takao, Yuji / Kohra, Shinya / Ishibashi, Yasuhiro / Tominaga, Nobuaki / Yoshihara, Shin'Ichi / Arizono, Koji
Issue Date: Feb-2005
Publisher: Pharmaceutical Society of Japan
Citation: Journal of Health Science v.51(1) p.93-95, 2005
Abstract: We investigated the estrogenic activity of a bisphenol A (BPA) metabolite (4-methyl-2,4-bis(p-hydroxyphenyl)-pent-1-ene; MBP) in male medaka (Oryzias latipes) using vitellogenin (Vg, Vg1 and Vg2) as a biomarker. Male d-rR medaka were exposed to various concentrations of estradiol-17β (E2), MBP and BPA for 3 days, and then the serum Vg concentration was measured using specific chemiluminescent immunoassays. The estimated relative estrogenic activities of MBP and BPA compared with E2 (100%) were 1.3-1.4% and 0.00010-0.00023%, respectively. These findings indicated that MBP has about 104-fold higher estrogenic potency than the parent BPA and about 1/50 that of E2 for Vg synthesis in medaka. This is the first study to show that MBP can act as a highly potent estrogen agonist in living organisms.
Keywords: bisphenol A metabolite / estrogenic activity / vitellogenin / 4-methyl-2,4-bis(p-hydroxyphenyl)-pent-1-ene / medaka
URI: http://hdl.handle.net/10069/8370
ISSN: 13449702
DOI: 10.1248/jhs.51.93
Relational Links: http://dx.doi.org/10.1248/jhs.51.93
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/8370

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