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Effects of Perfluoro Organic Compound Toxicity on Nematode Caenorhabditis elegans Fecundity


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タイトル: Effects of Perfluoro Organic Compound Toxicity on Nematode Caenorhabditis elegans Fecundity
著者: Tominaga, Nobuaki / Kohra, Shinya / Iguchi, Taisen / Arizono, Koji
発行日: 2004年10月
出版者: Pharmaceutical Society of Japan
引用: Journal of Health Science v.50(5) p.545-550, 2004
抄録: Toxicity studies using the nematode Caenorhabditis elegans (C. elegans) as a model organism have shown that perfluoro organic compounds have sub-lethal toxicity at the 10 pM-100 nM range on multi-generation assays. We examined the acute lethal toxicity and multi-generational sublethal toxicity (fecundity and reproduction) of perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA) and salts of perfluoro-1-octansulfonic acid (PFOS) using 1.7% agar Nematode Growth Medium (NGM) plates. The fluorine compounds affected the fecundity of C. elegans at concentrations 105- to 108-fold lower than the median effective concentrations (EC50). In particular, worm abundance during the first generation did not differ significantly from controls, while in contrast, the number of worms in the fourth generation at 10 pM PFOS-tetraethylammonium (TEA) decreased significantly to about 50% of control (p < 0.01) and the number of eggs and worms in the fourth generation at 1 nM PFNA decreased significantly to about 30% of control (p < 0.01). However, no dose-response relationship was observed in this study. We confirmed that perfluoro organic compounds strongly disrupt fecundity in C. elegans.
キーワード: Caenorhabditis elegans / sublethal toxicity / bioassay / perfluoro organic compound
URI: http://hdl.handle.net/10069/8371
ISSN: 13449702
DOI: 10.1248/jhs.50.545
関連リンク : http://dx.doi.org/10.1248/jhs.50.545
資料タイプ: Journal Article
原稿種類: publisher
出現コレクション:070 学術雑誌論文

引用URI : http://hdl.handle.net/10069/8371

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