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Caenorhabditis elegans Responses to Specific Steroid Hormones

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Title: Caenorhabditis elegans Responses to Specific Steroid Hormones
Authors: Tominaga, Nobuaki / Ura, Kazuhiro / Kawakami, Masato / Kawaguchi, Tomoaki / Kohra, Shinya / Mitsui, Yoshinori / Iguchi, Taisen / Arizono, Koji
Issue Date: Feb-2003
Publisher: Pharmaceutical Society of Japan
Citation: Journal of Health Science v.49(1) p.28-33, 2003
Abstract: In this paper, Caenorhabditis elegans (C. elegans) is proposed as a model organism for studying chemical effects over multiple generations. We investigated whether C. elegans responds to vertebrate steroid hormones. We found that estrogenic steroids, especially estradiol (E2), have a cholesterol-like potency in supporting the reproduction of C. elegans. In contrast, testosterone (TS) and diethylstilbestrol (DES) did not display this potency. On the other hand, E2, TS and DES supressed the fecundity rate of C. elegans, when culture carried out with cholesterol. Moreover effect of TS accumulated over generation, in contrast to the other chemicals tested. These data suggested that with convenient biomarkers such as fecundity, C. elegans might be an effective model organism for studying chemical actions, including the disruption of reproduction.
Keywords: Caenorhabditis elegans / reproduction / fecundity / endocrine disrupting chemical / steroid hormone
URI: http://hdl.handle.net/10069/8373
ISSN: 13449702
DOI: 10.1248/jhs.49.28
Relational Links: http://dx.doi.org/10.1248/jhs.49.28
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/8373

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