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Examination of the Nitric Oxide Production-Suppressing Component in Tinospora tuberculata

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タイトル: Examination of the Nitric Oxide Production-Suppressing Component in Tinospora tuberculata
著者: Yokozawa, Takako / Tanaka, Takashi / Kimura, Takeatsu
発行日: 2001年10月
出版者: Pharmaceutical Society of Japan
引用: Biological & Pharmaceutical Bulletin v.24(10) p.1153-1156, 2001
抄録: The component of aqueous Tinospora tuberculata extract that inhibits nitric oxide (NO) production was examined using macrophages activated by the addition of lipopolysaccharide. The aqueous extract was partitioned with ethyl acetate. The aqueous layer was fractionated with a Diaion column. The residue of the aqueous extract was extracted with methanol, and partitioned with ethyl acetate. The ethyl acetate layer was found to be associated with a distinct decrease in the NO level and inducible NO synthase. On further fractionation, the subfraction of E-3 showed high anti-NO activity. N-trans-Feruloyltyramine isolated from E-3 was identified as exhibiting strong anti-NO activity. This compound is the most active component of Tinospora tuberculata with respect to the suppression of NO production.
キーワード: Tinospora tuberculata / N-trans-feruloyltyramine / nitric oxide / inducible nitric oxide synthase / macrophage
URI: http://hdl.handle.net/10069/8374
ISSN: 09186158
DOI: 10.1248/bpb.24.1153
PubMed ID: 11642322
関連リンク : http://dx.doi.org/10.1248/bpb.24.1153
資料タイプ: Journal Article
原稿種類: publisher
出現コレクション:050 学術雑誌論文

引用URI : http://hdl.handle.net/10069/8374



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