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Examination of the Nitric Oxide Production-Suppressing Component in Tinospora tuberculata


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Title: Examination of the Nitric Oxide Production-Suppressing Component in Tinospora tuberculata
Authors: Yokozawa, Takako / Tanaka, Takashi / Kimura, Takeatsu
Issue Date: Oct-2001
Publisher: Pharmaceutical Society of Japan
Citation: Biological & Pharmaceutical Bulletin v.24(10) p.1153-1156, 2001
Abstract: The component of aqueous Tinospora tuberculata extract that inhibits nitric oxide (NO) production was examined using macrophages activated by the addition of lipopolysaccharide. The aqueous extract was partitioned with ethyl acetate. The aqueous layer was fractionated with a Diaion column. The residue of the aqueous extract was extracted with methanol, and partitioned with ethyl acetate. The ethyl acetate layer was found to be associated with a distinct decrease in the NO level and inducible NO synthase. On further fractionation, the subfraction of E-3 showed high anti-NO activity. N-trans-Feruloyltyramine isolated from E-3 was identified as exhibiting strong anti-NO activity. This compound is the most active component of Tinospora tuberculata with respect to the suppression of NO production.
Keywords: Tinospora tuberculata / N-trans-feruloyltyramine / nitric oxide / inducible nitric oxide synthase / macrophage
URI: http://hdl.handle.net/10069/8374
ISSN: 09186158
DOI: 10.1248/bpb.24.1153
PubMed ID: 11642322
Relational Links: http://dx.doi.org/10.1248/bpb.24.1153
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/8374

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