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Antiproliferative Constituents in the Plant 8. Seeds of Rhynchosia volubilis


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タイトル: Antiproliferative Constituents in the Plant 8. Seeds of Rhynchosia volubilis
著者: Kinjo, Junei / Nagao, Tsuneatsu / Tanaka, Takashi / Nonaka, Gen-Ichiro / Okabe, Hikaru
発行日: 2001年12月
出版者: Pharmaceutical Society of Japan
引用: Biological & Pharmaceutical Bulletin v.24(12) p.1443-1445, 2001
抄録: The MeOH extract of the seeds of Rhynchosia volubilis (Leguminosae) showed antiproliferative activity against human gastric adenocarcinoma [MK-1, 50% growth inhibition (GI50): 25 μg/ml], human uterus carcinoma (HeLa, GI50: 30 μg/ml), and murine melanoma (B16F10, GI50: 8 μg/ml) cells. Bioactivity-guided fractionation resulted in the isolation of gallic acid methylester (1), gallic acid (2), 7-O-galloylcatechin (3), 1,6-di-O-galloylglucose (4), 1-O-galloylglucose (5), and trigalloylgallic acid (6), and their antiproliferative activity was estimated. All showed much stronger inhibition against B16F10 cell growth than against HeLa and MK-1 cell growth. Compound 2 and its tetramer (6) with a free carboxyl group showed higher activity than those which did not have a free carboxyl group. In relation to the gallic acid tetramer (6), two gallic acid dimers (ellagic acid and dehydrodigallic acid) and trimers (tergallic acid dilactone and flavogallonic acid dilactone) were tested for their activity, and compared with those of the isolates.
キーワード: Rhynchosia volubilis / antiproliferative activity / polyphenol / gallic acid and related compound
URI: http://hdl.handle.net/10069/8375
ISSN: 09186158
DOI: 10.1248/bpb.24.1443
PubMed ID: 11767121
関連リンク : http://dx.doi.org/10.1248/bpb.24.1443
資料タイプ: Journal Article
原稿種類: publisher
出現コレクション:050 学術雑誌論文

引用URI : http://hdl.handle.net/10069/8375

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