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Kidney- and Site-Selective Delivery of 5-Fluorouracil Utilizing the Absorption on the Kidney Surface in Rats


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Title: Kidney- and Site-Selective Delivery of 5-Fluorouracil Utilizing the Absorption on the Kidney Surface in Rats
Authors: Kawakami, Shigeru / Horimoto, Tomomi / Nishida, Koyo / Hirayama, Ryu / Mukai, Takahiro / Nakashima, Mikiro / Sasaki, Hitoshi / Sakaeda, Toshiyuki / Nakamura, Junzo
Issue Date: Jul-2002
Publisher: Pharmaceutical Society of Japan
Citation: Biological & Pharmaceutical Bulletin v.25(7) p.928-930, 2002
Abstract: The present study was undertaken to elucidate the kidney- and site-selective delivery of 5-fluorouracil (5-FU) utilizing the absorption on the kidney surface in rats. An experimental system utilizing a cylindrical diffusion cell attached to the right kidney surface was established. After intravenous administration of 5-FU, the concentration of 5-FU in the right and left kidneys was almost the same and was rapidly eliminated. After right kidney surface application of 5-FU, however, the concentration of 5-FU in the right kidney was significantly higher than in the left kidney and other tissues. The 5-FU concentration in four sites of the right kidney after intravenous administration was almost the same. In contrast, 5-FU was site selectively delivered in the kidney after kidney surface application. The blood concentration of 5-FU was low (<1.7 μg/ml) until 120 min after kidney surface application. The maximum blood concentration of 5-FU after kidney surface application was much lower than after intravenous administration.
Keywords: 5-fluorouracil / kidney / targeting / drug delivery system / rat / anticancer drug
URI: http://hdl.handle.net/10069/8380
ISSN: 09186158
DOI: 10.1248/bpb.25.928
PubMed ID: 12132672
Relational Links: http://dx.doi.org/10.1248/bpb.25.928
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/8380

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