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Influence of Liver Disease on Phenolsulfonphthalein Absorption from Liver Surface to Examine Possibility of Direct Liver Surface Application for Drug Targeting


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タイトル: Influence of Liver Disease on Phenolsulfonphthalein Absorption from Liver Surface to Examine Possibility of Direct Liver Surface Application for Drug Targeting
著者: Nishida, Koyo / Honda, Tominori / Nakashima, Mikiro / Sasaki, Hitoshi / Nakamura, Junzo
発行日: 2003年 7月
出版者: Pharmaceutical Society of Japan
引用: Biological & Pharmaceutical Bulletin v.26(7) p.988-993, 2003
抄録: We have examined the influence of liver disease on drug absorption from the liver surface membrane, regarded as the first barrier for drug targeting to the liver. The main purpose of this study is to examine the possibility of direct liver surface application as a drug targeting method. We employed rats intoxicated with carbon tetrachloride (CCl4) or D-galactosamine (GAL) as the liver disease model, and examined drug absorption characteristics after application to the liver surface, by utilizing a cylindrical diffusion cell. In the liver-intoxicated rats, about 90% of a low molecular weight drug, phenolsulfonphthalein (PSP), as a model was absorbed from the liver surface in 6 h, similar to the normal rats (no treatment). Although the absorption rate was increased in the CCl4 group, whereas slightly retarded absorption was observed in GAL group, there should be no serious problem for the clinical use of liver surface application. The PSP absorption from the liver surface in the CCl4 group was indicated to obey first-order kinetics by elimination profile from the diffusion cell. The first-order absorption rate constant Ka values of PSP from the liver surface, obtained by a compartment model and elimination profile, were increased 1.3-fold in the CCl4 group compared to the control. Moreover, we performed drug application to the liver surface in the peritoneal cavity to assume clinical use. The Ka of PSP in the CCl4 group was about 4-fold larger than in the normal group, implying the importance of estimating changes in peritoneal drug absorption as a result of liver disease. Consequently, it is expected that there will be no marked decline in the absorption rate from the liver surface in a liver disease state, leading us to apply this administration method for liver targeting.
キーワード: drug targeting / liver disease / absorption / organ surface
URI: http://hdl.handle.net/10069/8384
ISSN: 09186158
DOI: 10.1248/bpb.26.988
PubMed ID: 12843624
関連リンク : http://dx.doi.org/10.1248/bpb.26.988
資料タイプ: Journal Article
原稿種類: publisher
出現コレクション:050 学術雑誌論文

引用URI : http://hdl.handle.net/10069/8384

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