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Antiproliferative Activity of the Main Constituents from Phyllanthus emblica


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Title: Antiproliferative Activity of the Main Constituents from Phyllanthus emblica
Authors: Zhang, Ying-Jun / Nagao, Tsuneatsu / Tanaka, Takashi / Yang, Chong-Ren / Okabe, Hikaru / Kouno, Isao
Issue Date: Feb-2004
Publisher: Pharmaceutical Society of Japan
Citation: Biological & Pharmaceutical Bulletin v.27(2) p.251-255, 2004
Abstract: Eighteen main compounds, including four norsesquiterpenoids (1?4) and 14 phenolic compounds (5?18) isolated previously from Phyllanthus emblica, together with a main constituent, proanthocyanidin polymers (19) identified at this time from the roots, were estimated for their antiproliferative activities against MK-1 (human gastric adenocarcinoma), HeLa (human uterine carcinoma), and B16F10 (murine melanoma) cells using an MTT method. All of the phenolic compounds including the major components 5?8 from the fruit juice, 8, 9, and 12 from the branches and leaves, and 19 from the roots showed stronger inhibition against B16F10 cell growth than against HeLa and MK-1 cell growth. Norsesquiterpenoid glycosides 3 and 4 from the roots exhibited significant antiproliferative activities, although their aglycon 1 and monoglucoside 2 showed no inhibitory activity against these tumor cells.
Keywords: Phyllanthus emblica / Euphorbiaceae / antiproliferative activity / MK-1 cell / HeLa cell / B16F10 cell
URI: http://hdl.handle.net/10069/8387
ISSN: 09186158
DOI: 10.1248/bpb.27.251
PubMed ID: 14758047
Relational Links: http://dx.doi.org/10.1248/bpb.27.251
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/8387

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