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Antiproliferative Activity of the Main Constituents from Phyllanthus emblica

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タイトル: Antiproliferative Activity of the Main Constituents from Phyllanthus emblica
著者: Zhang, Ying-Jun / Nagao, Tsuneatsu / Tanaka, Takashi / Yang, Chong-Ren / Okabe, Hikaru / Kouno, Isao
発行日: 2004年 2月
出版者: Pharmaceutical Society of Japan
引用: Biological & Pharmaceutical Bulletin v.27(2) p.251-255, 2004
抄録: Eighteen main compounds, including four norsesquiterpenoids (1?4) and 14 phenolic compounds (5?18) isolated previously from Phyllanthus emblica, together with a main constituent, proanthocyanidin polymers (19) identified at this time from the roots, were estimated for their antiproliferative activities against MK-1 (human gastric adenocarcinoma), HeLa (human uterine carcinoma), and B16F10 (murine melanoma) cells using an MTT method. All of the phenolic compounds including the major components 5?8 from the fruit juice, 8, 9, and 12 from the branches and leaves, and 19 from the roots showed stronger inhibition against B16F10 cell growth than against HeLa and MK-1 cell growth. Norsesquiterpenoid glycosides 3 and 4 from the roots exhibited significant antiproliferative activities, although their aglycon 1 and monoglucoside 2 showed no inhibitory activity against these tumor cells.
キーワード: Phyllanthus emblica / Euphorbiaceae / antiproliferative activity / MK-1 cell / HeLa cell / B16F10 cell
URI: http://hdl.handle.net/10069/8387
ISSN: 09186158
DOI: 10.1248/bpb.27.251
PubMed ID: 14758047
関連リンク : http://dx.doi.org/10.1248/bpb.27.251
資料タイプ: Journal Article
原稿種類: publisher
出現コレクション:050 学術雑誌論文

引用URI : http://hdl.handle.net/10069/8387



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