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Cell Death Mode Switch from Necrosis to Apoptosis in Brain

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Title: Cell Death Mode Switch from Necrosis to Apoptosis in Brain
Authors: Ueda, Hiroshi / Fujita, Ryousuke
Issue Date: Jul-2004
Publisher: Pharmaceutical Society of Japan
Citation: Biological & Pharmaceutical Bulletin v.27(7) p.950-955, 2004
Abstract: In brain ischemia, cell destructive necrosis occurs in the core, which in turn links to cell death expansion in the vicinity. Apoptosis, on the other hand, occurs in the surroundings of the core, called the penumbra, several days later. As cells showing apoptosis disappear by microglial phagocytosis in the brain, cell death induced by ischemic stress should eventually be terminated. Thus, the authors propose the hypothesis that the cell death mode switch in the event of brain ischemia is an in vivo self-protective mechanism. The authors attempt to overview the current understanding of the molecular mechanisms of necrosis and apoptosis in relation to the ATP hypothesis, and also introduce novel mechanisms for an in vitro cell death mode switch.
Keywords: necrosis / apoptosis / cell death mode switch / ischemia / ATP
URI: http://hdl.handle.net/10069/8390
ISSN: 09186158
DOI: 10.1248/bpb.27.950
PubMed ID: 15256720
Relational Links: http://dx.doi.org/10.1248/bpb.27.950
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/8390

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