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Cell Death Mode Switch from Necrosis to Apoptosis in Brain

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タイトル: Cell Death Mode Switch from Necrosis to Apoptosis in Brain
著者: Ueda, Hiroshi / Fujita, Ryousuke
発行日: 2004年 7月
出版者: Pharmaceutical Society of Japan
引用: Biological & Pharmaceutical Bulletin v.27(7) p.950-955, 2004
抄録: In brain ischemia, cell destructive necrosis occurs in the core, which in turn links to cell death expansion in the vicinity. Apoptosis, on the other hand, occurs in the surroundings of the core, called the penumbra, several days later. As cells showing apoptosis disappear by microglial phagocytosis in the brain, cell death induced by ischemic stress should eventually be terminated. Thus, the authors propose the hypothesis that the cell death mode switch in the event of brain ischemia is an in vivo self-protective mechanism. The authors attempt to overview the current understanding of the molecular mechanisms of necrosis and apoptosis in relation to the ATP hypothesis, and also introduce novel mechanisms for an in vitro cell death mode switch.
キーワード: necrosis / apoptosis / cell death mode switch / ischemia / ATP
URI: http://hdl.handle.net/10069/8390
ISSN: 09186158
DOI: 10.1248/bpb.27.950
PubMed ID: 15256720
関連リンク : http://dx.doi.org/10.1248/bpb.27.950
資料タイプ: Journal Article
原稿種類: publisher
出現コレクション:050 学術雑誌論文

引用URI : http://hdl.handle.net/10069/8390



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