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Stomach- and Site-Selective Delivery of 5-Fluorouracil Following Its Application on the Gastric Serosal Surface in Rats


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Title: Stomach- and Site-Selective Delivery of 5-Fluorouracil Following Its Application on the Gastric Serosal Surface in Rats
Authors: Nakamura, Junzo / Kobayashi, Kazuko / Fumoto, Shintaro / Nishi, Junya / Mukai, Takahiro / Nakashima, Mikiro / Sasaki, Hitoshi / Nishida, Koyo
Issue Date: Jun-2005
Publisher: Pharmaceutical Society of Japan
Citation: Biological & Pharmaceutical Bulletin v.28(6) p.1049-1053, 2005
Abstract: The present study was undertaken to elucidate the stomach- and site-selective delivery of 5-fluorouracil (5-FU) following its application on the gastric serosal surface in rats. An experimental system utilizing a cylindrical diffusion cell attached to the gastric serosal surface was established. To evaluate the gastric distribution of 5-FU, the stomach was separated into the site under the diffusion cell (site 1) and the site not under the diffusion cell (site 2). Furthermore, the mucosal side at site 1 was separated from the serosal side. After intravenous and oral administration of 5-FU, the 5-FU concentrations at sites 1 and 2 until 240 min were similar. After gastric serosal surface application of 5-FU, however, the concentration of 5-FU at site 1 until 240 min was approximately 10-fold higher than that at site 2, and was sustained. Furthermore, the 5-FU concentration on the mucosal side at site 1 and the serosal side at site 1 were comparable after gastric serosal surface application. The blood concentration of 5-FU was low (<4.4 μg/ml) until 240 min after gastric serosal surface application. The maximum blood concentration of 5-FU after gastric serosal surface application was significantly lower than after intravenous administration. Thus, the stomach- and site-selective delivery system following application on the gastric serosal surface could be applied with anticancer drugs for the treatment of gastric cancer.
Keywords: gastric cancer / chemotherapy / stomach targeting / drug delivery system / 5-fluorouracil / rat
URI: http://hdl.handle.net/10069/8391
ISSN: 09186158
DOI: 10.1248/bpb.28.1049
PubMed ID: 15930743
Relational Links: http://dx.doi.org/10.1248/bpb.28.1049
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/8391

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