DSpace university logo mark
Japanese | English 

NAOSITE : Nagasaki University's Academic Output SITE > 050 薬学部 > 050 学術雑誌論文 >

Surface Plasmon Resonance Analysis for the Screening of Anti-prion Compounds

ファイル 記述 サイズフォーマット
BPBul29_927.pdf324.58 kBAdobe PDF本文ファイル

タイトル: Surface Plasmon Resonance Analysis for the Screening of Anti-prion Compounds
著者: Kawatake, Satoshi / Nishimura, Yuki / Sakaguchi, Suehiro / Iwaki, Toru / Doh-Ura, Katsumi
発行日: 2006年 5月
出版者: Pharmaceutical Society of Japan
引用: Biological & Pharmaceutical Bulletin v.29(5) p.927-932, 2006
抄録: The interaction of anti-prion compounds and amyloid binding dyes with a carboxy-terminal domain of prion protein (PrP121?231) was examined using surface plasmon resonance (SPR) and compared with inhibition activities of abnormal PrP formation in scrapie-infected cells. Most examined compounds had affinities for PrP121?231: antimalarials had low affinities, whereas Congo red, phthalocyanine and thioflavin S had high affinities. The SPR binding response correlated with the inhibition activity of abnormal PrP formation. Several drugs were screened using SPR to verify the findings: propranolol was identified as a new anti-prion compound. This fact indicates that drug screenings by this assay are useful.
キーワード: anti-prion compound / surface plasmon resonance / scrapie-infected cell / screening / recombinant prion protein
URI: http://hdl.handle.net/10069/8397
ISSN: 09186158
DOI: 10.1248/bpb.29.927
PubMed ID: 16651721
関連リンク : http://dx.doi.org/10.1248/bpb.29.927
資料タイプ: Journal Article
原稿種類: publisher
出現コレクション:050 学術雑誌論文

引用URI : http://hdl.handle.net/10069/8397



Valid XHTML 1.0! Copyright © 2006-2015 長崎大学附属図書館 - お問い合わせ Powerd by DSpace