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Separation of Sympathomimetic Amines of Abuse and Related Compounds by Micellar Electrokinetic Chromatography


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タイトル: Separation of Sympathomimetic Amines of Abuse and Related Compounds by Micellar Electrokinetic Chromatography
著者: Kuroda, Naotaka / Sato, Daisuke / Ohyama, Kaname / Wada, Mitsuhiro / Nakahara, Yuji / Nakashima, Kenichiro
発行日: 2001年 7月
出版者: Pharmaceutical Society of Japan
引用: Chemical & Pharmaceutical Bulletin v.49(7) p.905-908, 2001
抄録: Separation of twelve sympathomimetic amines and related compounds by micellar electrokinetic chromatography (MEKC) with UV absorbance detection is described. These amines were well separated within 25 min using 50 mM sodium tetraborate solution containing 15 mM sodium dodecylsulfate (SDS) of pH 9.3 as a running solution and detected at 210 nm. MEKC was performed with an applied voltage of 13 kV at 25 °C using a fused-silica capillary (50 cm×75 mm i.d.) with effective length of 37.5 cm. The detection limits of these compounds were in the range from 4 to 97 fmol/injection at a signal-to-noise ratio (S/N) of 3. The reproducibility of the method expressed as relative standard deviation (RSD) for within-day (n=6) and between-day (n=5) assays was less than 4.8 and 8.8%, respectively. The proposed method could be applied to the determination of an anorectic drug, phentermine, in Chinese tea with a detection limit of 99 μg/g (105 fmol/injection, S/N=3).
キーワード: micellar electrokinetic chromatography / sympathomimetic amine / phentermine / Chinese tea
URI: http://hdl.handle.net/10069/8403
ISSN: 00092363
DOI: 10.1248/cpb.49.905
PubMed ID: 11456100
関連リンク : http://dx.doi.org/10.1248/cpb.49.905
資料タイプ: Journal Article
原稿種類: publisher
出現コレクション:050 学術雑誌論文

引用URI : http://hdl.handle.net/10069/8403

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