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Regulation of Lithospermic Acid B and Shikonin Production in Lithospermum erythrorhizon Cell Suspension Cultures

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タイトル: Regulation of Lithospermic Acid B and Shikonin Production in Lithospermum erythrorhizon Cell Suspension Cultures
著者: Yamamoto, Hirobumi / Zhao, Ping / Yazaki, Kazufumi / Inoue, Kenichiro
発行日: 2002年 8月
出版者: Pharmaceutical Society of Japan
引用: Chemical & Pharmaceutical Bulletin v.50(8) p.1086-1090, 2002
抄録: Cell suspension cultures of Lithospermum erythrorhizon produced a large amount of lithospermic acid B, a caffeic acid tetramer, as well as shikonin derivatives (each ca. 10% of dry wt.) when cultured in shikonin production medium M-9. Various culture factors for increasing the production of lithospermic acid B were investigated. Lithospermic acid B production was inhibited by 2, 4-D or NH4+, whereas it was stimulated by Cu2+. These regulatory patterns were similar to those for the production of shikonin derivatives in these cell cultures, suggestive of close relations and similar metabolic regulation between the production of these compounds. Cultivation under light illumination, however, showed that these metabolisms were independently regulated. In particular, blue light showed a stimulatory effect on lithospermic acid B production, while shikonin production was strongly inhibited, indicative of an effective condition for lithospermic acid B production.
キーワード: Lithospermum erythrorhizon / plant cell culture / lithospermic acid B / shikonin / light / nitrogen source
URI: http://hdl.handle.net/10069/8405
ISSN: 00092363
DOI: 10.1248/cpb.50.1086
PubMed ID: 12192141
関連リンク : http://dx.doi.org/10.1248/cpb.50.1086
資料タイプ: Journal Article
原稿種類: publisher
出現コレクション:050 学術雑誌論文

引用URI : http://hdl.handle.net/10069/8405



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