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Penicillamine Selenotrisulfide as a Selenium-Source in Mice

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タイトル: Penicillamine Selenotrisulfide as a Selenium-Source in Mice
著者: Haratake, Mamoru / Ono, Masahiro / Nakayama, Morio
発行日: 2004年 8月
出版者: Pharmaceutical Society of Japan
引用: Journal of Health Science v.50(4) p.366-371, 2004
抄録: In this paper, we compared the bioavailability of penicillamine selenotrisulfide (PenSSeSPen) with the authentic selenium-source compound, selenite. When PenSSeSPen was orally administered to selenium-deficient mice for 7 days, selenium contents of blood, liver and heart significantly increased as well as selenite. In addition, when PenSSeSPen-supplemented diet was fed to 3-week old mice for 7 weeks, selenium contents of selected organs were almost the same as those of selenite, and hepatic cellular glutathione peroxidase (GPx) activity was also observed. These facts evidently indicate that PenSSeSPen, a totally foreign selenium compound, serves as a selenium-source compound.
キーワード: bioavailability / selenotrisulfide / selenium / mice
URI: http://hdl.handle.net/10069/8410
ISSN: 13449702
DOI: 10.1248/jhs.50.366
関連リンク : http://dx.doi.org/10.1248/jhs.50.366
資料タイプ: Journal Article
原稿種類: publisher
出現コレクション:050 学術雑誌論文

引用URI : http://hdl.handle.net/10069/8410



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