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Penicillamine Selenotrisulfide as a Selenium-Source in Mice


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Title: Penicillamine Selenotrisulfide as a Selenium-Source in Mice
Authors: Haratake, Mamoru / Ono, Masahiro / Nakayama, Morio
Issue Date: Aug-2004
Publisher: Pharmaceutical Society of Japan
Citation: Journal of Health Science v.50(4) p.366-371, 2004
Abstract: In this paper, we compared the bioavailability of penicillamine selenotrisulfide (PenSSeSPen) with the authentic selenium-source compound, selenite. When PenSSeSPen was orally administered to selenium-deficient mice for 7 days, selenium contents of blood, liver and heart significantly increased as well as selenite. In addition, when PenSSeSPen-supplemented diet was fed to 3-week old mice for 7 weeks, selenium contents of selected organs were almost the same as those of selenite, and hepatic cellular glutathione peroxidase (GPx) activity was also observed. These facts evidently indicate that PenSSeSPen, a totally foreign selenium compound, serves as a selenium-source compound.
Keywords: bioavailability / selenotrisulfide / selenium / mice
URI: http://hdl.handle.net/10069/8410
ISSN: 13449702
DOI: 10.1248/jhs.50.366
Relational Links: http://dx.doi.org/10.1248/jhs.50.366
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/8410

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