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High-Performance Liquid Chromatographic Analysis of Drugs of Abuse in Biologic Samples


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タイトル: High-Performance Liquid Chromatographic Analysis of Drugs of Abuse in Biologic Samples
著者: Nakashima, Kenichiro
発行日: 2005年 6月
出版者: Pharmaceutical Society of Japan
引用: Journal of Health Science v.51(3) p.272-277, 2005
抄録: Recently, drug abuse has become a serious social problem world wide. In Japan, methamphetamine (MP) is the most popular drug of abuse. In addition to MP, the use of 4,5-methylenedioxymethamphetamine (MDMA), called ecstacy, is rapidly increasing, especially among young people. The development of simple and convenient analytical methods for the analysis of these drugs of abuse is necessary for the prediction of and protection from human health risks. Many useful methods have been developed for qualification and quantification of drugs of abuse. Among these, gas chromatography with mass spectrometry (MS) and high-performance liquid chromatography with MS (HPLC-MS or LC-MS) or fluorescence (HPLC-FL) detection are widely used. As highly sensitive methods, precolumn or postcolumn derivatization methods are commonly utilized in HPLC. This review focuses on HPLC methods used for the practical analysis of drugs of abuse, mainly for amphetamine derivatives and MDMAs in biologic samples such as urine, blood, and hair.
キーワード: analysis / drug abuse / high-performance liquid chromatography
URI: http://hdl.handle.net/10069/8411
ISSN: 13449702
DOI: 10.1248/jhs.51.272
関連リンク : http://dx.doi.org/10.1248/jhs.51.272
資料タイプ: Journal Article
原稿種類: publisher
出現コレクション:050 学術雑誌論文

引用URI : http://hdl.handle.net/10069/8411

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