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Insulin as the "Primary" Autoantigen in Type 1 Diabetes?


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Title: Insulin as the "Primary" Autoantigen in Type 1 Diabetes?
Authors: Abiru, Norio
Issue Date: Jun-2004
Citation: Acta medica Nagasakiensia. 2004, 49(1-2), p.1-6
Abstract: Type 1 diabetes of both the human and NOD mouse is associated with autoimmunity directed against insulin which is the only β cell specific autoantigen. Variable number of tandem repeats in the 5′ region of insulin gene on chromosome 11 is associated with the risk of type 1 diabetes in human. Mice have two insulin genes including the insulin 1 gene (chromsome 19) and the insulin 2 gene (chromsome 7). The insulin 2 gene knockout when bred onto NOD mice accelerates diabetes. In contrast to insulin 2, diabetes and insulitis were markedly reduced in insulin 1 knockout mice with decreased and delayed diabetes. Autoantibodies to insulin can predict diabetes in man and NOD mice. Insulin peptides can be used to induce insulitis and diabetes in non-diabetic strain mice. Our results suggest that insulin molecule is a possible "primary" autoantigen that initiates a pathogenesis of type 1 diabetes. An administration of insulin or its peptide can prevent the development of diabetes in NOD mice but we cannot at present safely prevent type 1 diabetes in humans. A series of clinical trials are under way and planned.
Keywords: Type1diabetes / NODmouse / Insulingene / Insulinautoantibody / InsulinBchainpeptide
URI: http://hdl.handle.net/10069/9257
ISSN: 00016055
Relational Links: http://joi.jlc.jst.go.jp/JST.JSTAGE/amn/49.1
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 49, No. 1-2

Citable URI : http://hdl.handle.net/10069/9257

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