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Contribution of Bystander Effects in Radiation Induced Genotoxicity


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Title: Contribution of Bystander Effects in Radiation Induced Genotoxicity
Authors: Zhou, Hongning / Suzuki, Masao / Persaud, Rudranath / Gillispie, Joseph / Randers-Pehrson, Gerhard / K.Hei, Tom
Issue Date: Dec-2005
Citation: Acta medica Nagasakiensia. 2005, 50(supl.1), p.73-77
Abstract: The controversial use of a linear, no threshold extrapolation model for low dose risk assessment is based on the accepted dogma that the deleterious effects of ionizing radiation such as mutagenesis and carcinogenesis are attributable mainly to direct damage to DNA. However, this extropolation was challenged by the recent reports on the bystander phenomenon. The bystander effect contributes to this debate by implying that the biological effects of low doses, where not all cells are traversed by a charged particle, are amplified by the transfer of factors to un-irradiated neighbors. This interested phenomenon implies that a linear extrapolation of risks from high to low doses may underestimate rather than over estimate low dose risks. Together with some radiation-induced phenomena such as adaptive response and genomic instability, the radiobiological response at low doses is likely to be a complex interplay among many factors.
Keywords: Radiationrisk / Microbeam / Bystandereffect / Genotoxicity
URI: http://hdl.handle.net/10069/9316
ISSN: 00016055
Relational Links: http://joi.jlc.jst.go.jp/JST.JSTAGE/amn/50.S73
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 50, No. supl.1

Citable URI : http://hdl.handle.net/10069/9316

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