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Segmental Jumping Translocation of Ret Oncogene in Radiation-associated Thyroid Cancer

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Title: Segmental Jumping Translocation of Ret Oncogene in Radiation-associated Thyroid Cancer
Authors: Nakashima, Masahiro / Takamura, Noboru / Namba, Hiroyuki / Saenko, Vladimir / Hayashi, Tomayoshi / Sekine, Ichiro
Issue Date: Dec-2005
Citation: Acta medica Nagasakiensia. 2005, 50(supl.1), p.87-89
Abstract: Radiation etiology is well known in thyroid carcinogenesis. Ret rearrangement is the commonest oncogenic alterations in Chernobyl-related papillary thyroid cancer (PTC). To evaluate whether there is a radiation signature, we analyzed Ret rearrangement in radiation-associated thyroid cancers with fluorescence in situ hybridization (FISH) and reverse transcriptase-polymerase chain reaction (RT-PCR). The FISH analysis demonstrated segmental jumping translocation (SJT) of Ret gene in radiation-associated thyroid cancers but not in sporadic well differentiated PTC. Furthermore, Ret SJT was commonly observed in anaplastic thyroid cancer (ATC) including both radiation-associated and sporadic cancers. In PTC, Ret SJT was restricted to radiation-associated or high-grade cases. Because Ret SJT was not observed in sporadic, well differentiated and low-grade cases of PTC, Ret SJT might be a molecular marker for radiation-induced and/or aggressive cases of PTC. SJTs are unbalanced translocations involving a donor chromosome arm or chromosome segment that has fused to multiple recipient chromosome, and mainly reported in treatment-related leukemias, while very rare in solid cancers. We found SJT in radiation-induced and high-grade thyroid cancers, suggesting chromosomal instability. This is the first report showing SJT in thyroid cancer, and probably the third report showing SJT in solid cancer in vivo.
Keywords: Radiation / Thyroidcancer / Segmentaljumpingtranslocation / Ret
URI: http://hdl.handle.net/10069/9318
ISSN: 00016055
Relational Links: http://joi.jlc.jst.go.jp/JST.JSTAGE/amn/50.S87
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 50, No. supl.1

Citable URI : http://hdl.handle.net/10069/9318

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