DSpace university logo mark
詳細検索
Japanese | English 

NAOSITE : Nagasaki University's Academic Output SITE > 030 医学部 > 030 紀要 > Acta Medica Nagasakiensia > Volume 50, No. 1 >

Usefulness of Transdermal Glyceryl Trinitrate for Radial Arterial Spasm on Arteriovenous Hemodialysis Fistula Operation in Uremic Patients


ファイル 記述 サイズフォーマット
acta50_01_23.pdf222.95 kBAdobe PDF本文ファイル

タイトル: Usefulness of Transdermal Glyceryl Trinitrate for Radial Arterial Spasm on Arteriovenous Hemodialysis Fistula Operation in Uremic Patients
著者: Hirashima, Sadamu / Noguchi, Mitsuru / Horita, Yoshio / Matsuo, Manabu / Tadokoro, Masato / Taura, Kouichi / Kanetake, Hiroshi
発行日: 2005年 3月
引用: Acta medica Nagasakiensia. 2005, 50(1), p.23-28
抄録: Vasospasm sometimes disturbs successful blood access for hemodialysis, and prevention of vasospasm is desirable when constructing arteriovenous fistulae. We first investigated vasospasm of the radial artery in this operation and analyzed factors associated with this phenomenon in 20 patients with end-stage renal disease. Alteration of blood flow in the radial artery was evaluated in them, and intima-media thickness (IMT), endothelial function index (EFI) and laboratory data were analyzed. Vasospasm occurred in 9 of 20 cases (45.0%) at 5 min after anastomosis, and displayed a marginally significant correlation (r=0.31, p=0.081) with EFI. We then conducted a randomized study of 84 patients with end-stage renal disease to examine the effects of administering transdermal glyceryl trinitrate (GTN) in this operation. EFI was significantly correlated with IMT (r= -0.45, p<0.001). At 5 min after anastomosis, vasospasm occurred in 12 (28.6%) of 42 patients who were administered GTN, while it occurred in 20 (47.6%) of 42 patients without GTN administration (controls); the difference was marginally significant (p=0.072). In patients with IMT?1.1, alteration of diameter (5 min/1 min after anastomosis) was significantly reduced compared with controls (p=0.032). These data suggest that IMT could offer a predictor of vasospasm occurrence during arteriovenous fistula operations. Use of preoperative transdermal GTN may be effective in preventing vasospasm during such surgery.
キーワード: Arteriovenoushemodialysisfistula / Intima-mediathickness / Vasospasm / Endothelialfunction / Glyceryltrinitrate
URI: http://hdl.handle.net/10069/9324
ISSN: 00016055
関連リンク : http://joi.jlc.jst.go.jp/JST.JSTAGE/amn/50.23
資料タイプ: Departmental Bulletin Paper
原稿種類: publisher
出現コレクション:Volume 50, No. 1

引用URI : http://hdl.handle.net/10069/9324

このリポジトリに保管されている文献はすべて著作権により保護されています。
印刷やダウンロード等データの複製は、調査研究・教育または学習を目的とする場合に限定されます。

 

Valid XHTML 1.0! Copyright © 2006-2015 長崎大学附属図書館 - お問い合わせ Powerd by DSpace