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Impact of Treatment for Gastroesophageal Varices on Survival in Patients with Hepatocellular Carcinoma


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Title: Impact of Treatment for Gastroesophageal Varices on Survival in Patients with Hepatocellular Carcinoma
Authors: Mizuta, Yohei / Omagari, Katsuhisa / Ohba, Kazuo / Kadokawa, Yoshiko / Ohnita, Ken / Takeshima, Fuminao / Isomoto, Hajime / Kohno, Shigeru
Issue Date: Sep-2005
Citation: Acta medica Nagasakiensia. 2005, 50(3), p.101-106
Abstract: New treatment modalities have been introduced to manage gastroesophageal varices, but their impact on prognosis of patients with the varices and hepatocellular carcinoma is not conclusive. The aim of the present study was to evaluate the influences of the variceal treatment on survival of such patients. Seventy-five patients, who were given a diagnosis of hepatocellular carcinoma and died between 1997 and 2004, were retrospectively reviewed in the endoscopic findings and treatments of gastroesophageal varices and causes of death. Additionally, the survival curves were compared between the groups with and without gastroesophageal varices or between the groups with and without the variceal treatments. Sixty (80.0%) of 75 patients had gastroesophageal varices, and 16 (26.7%) among them received the variceal treatments for variceal bleeding or the risk. Nine patients were endoscopically proven esophageal variceal bleeding, and 5 of them had received primary prophylaxis. Fifty-two (69.3%) and 2 (2.7%) of 75 patients died of the progression of hepatocellular carcinoma and the variceal bleeding, respectively. No significant difference was observed in the distribution of causes of death between patients with and without gastroesophageal varices (p=0.7695), while in patients with varices, the distribution of causes of death significantly differed between those with and without therapy (p=0.0020). Survival curves, however, did not differ significantly either between the groups with and wthout gastroesophageal varices (p=0.5502) or between the groups with and without variceal treatments (p=0.4446). Our study suggests that the overall survival rates in patients with hepatocallular carcinoma may be not affected by gastroesophageal varices if the varices are treated depending on the conditions. This may be originated from the improved management of varices in addition to the limited life-span because of tumor progression.
Keywords: Gastroesophagealvarices / Hepatocellularcarcinoma / Survivaltime / Varicealtreatment
URI: http://hdl.handle.net/10069/9338
ISSN: 00016055
Relational Links: http://joi.jlc.jst.go.jp/JST.JSTAGE/amn/50.101
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 50, No. 3

Citable URI : http://hdl.handle.net/10069/9338

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