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Secondary In Vitro Sensitization of T Cells with Respect to Adoptive Immunotherapy for Cancer: Spread and Clonal Proliferation of Lymphocytes of Different T-Cell Subsets


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Title: Secondary In Vitro Sensitization of T Cells with Respect to Adoptive Immunotherapy for Cancer: Spread and Clonal Proliferation of Lymphocytes of Different T-Cell Subsets
Authors: Raichev, Ivan
Issue Date: Sep-2006
Citation: Acta medica Nagasakiensia. 2006, 51(3), p.79-87
Abstract: For the aim of adoptive immunotherapy in mice bearing transplanted sarcoma and in cancer patients, we performed secondary in vitro sensitization to obtain functionally active T cells. Specific tumor antigens, cytokines, viable irradiated tumor cells, an anti-CD3 monoclonal antibody and others were used. We preferred the method of complex stimulation with PHA, T-cell growth factor or IL-2, in small doses, and 3 M KCl tumor extract. In patients with cancer, many authors reported for an activity of cells with suppressor function. CD4+CD25+ regulatory T cells increased in number in peripheral blood and lymph node lymphocytes, and among tumor-infiltrating cells. In our investigations, production both of factor, inhibiting Ehrlich-cell migration and suppressor factor was revealed from T cells, in vitro sensitized with 3 M KCl cancer extract containing solubilized cancer antigens. The suppressor factor decreased or abrogated the effect of the inhibitory Ehrlich-cell migration factor. It is important to further scrutinize the spread and clonal proliferation of in vitro sensitized, transferred T cells, thus, their subsequent invasion in cancer node, in the host.
Keywords: Secondaryinvitrosensitization / Cancerextract / Inhibitoryfactor / RegulatoryTcells / Paracorticalactivity
URI: http://hdl.handle.net/10069/9365
ISSN: 00016055
Relational Links: http://joi.jlc.jst.go.jp/JST.JSTAGE/amn/51.79
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 51, No. 3

Citable URI : http://hdl.handle.net/10069/9365

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