DSpace university logo mark
Japanese | English 

NAOSITE : Nagasaki University's Academic Output SITE > 030 医学部 > 030 紀要 > Acta Medica Nagasakiensia > Volume 52, No. 2 >

Clinicopathological Analysis of the Expression of CD44v6 in Primary Thyroid Cancer and Recurrent Regional Lymph Nodes

ファイル 記述 サイズフォーマット
acta52_02_53.pdf863.1 kBAdobe PDF本文ファイル

タイトル: Clinicopathological Analysis of the Expression of CD44v6 in Primary Thyroid Cancer and Recurrent Regional Lymph Nodes
著者: Uga, Tatsuya / Maeda, Shigeto / Iwata, Tohru / Furui, Junichiro / Kanematsu, Takashi
発行日: 2007年 6月
引用: Acta medica Nagasakiensia. 2007, 52(2), p.53-57
抄録: Although the prognosis of differentiated thyroid cancer is generally favorable, some patients develop progressive disease resulting in a life-threatening condition and occasionally fatal outcome. CD44v6 is known to be a marker linked to distant metastasis in several types of human malignancy. In the present study, we analyzed the expression of CD44v6 in primary tumors and recurrent disease in the regional lymph node and evaluated its correlation with clinical variables and prognostic factors in patients with differentiated thyroid cancer. CD44v6 expression in the primary tumor was immunohistochemically detected in 58 of 79 patients (73%). Among parameters investigated, none except patient age showed a correlation with CD44v6 expression; the rate of positivity for CD44v6 was significantly higher (p=0.023) in patients aged 50 years or less than in those aged over 50 years. During the follow-up period, 14 patients were found to have recurrent cancer in regional lymph nodes, and among these, distant metastases were later detected in bones and/or lungs in 6 patients. Although an overall correlation between the expression of CD44v6 in the regional recurrent site and in distant metastasis was not statistically significant, there was a tendency that patients with positive CD44v6 in the regional lymph nodes subsequently developed distant matastases. CD44v6 appears to play an important role in tumor progression in patients with differentiated thyroid cancer, particularly in terms of recurrent disease in regional lymph nodes.
URI: http://hdl.handle.net/10069/9394
ISSN: 00016055
関連リンク : http://joi.jlc.jst.go.jp/JST.JSTAGE/amn/52.53
資料タイプ: Departmental Bulletin Paper
原稿種類: publisher
出現コレクション:Volume 52, No. 2

引用URI : http://hdl.handle.net/10069/9394



Valid XHTML 1.0! Copyright © 2006-2015 長崎大学附属図書館 - お問い合わせ Powerd by DSpace